gap open罚分小gap extend罚分大，gap分散出现，因为gap extend的代价更大gap open罚分大gap extend罚分小，gap出现集中，因为gap open的代价更大
gap open罚分小gap extend罚分大，gap分散出现，因为gap extend的代价更大
第三章：序列比较（第一部分） 课时 3.1 认识序列 3.2 序列相似性 3.3 替换记分矩阵 3.4 序列两两比较：打点法 3.5 序列两两比较：序列比对法 3.6 一致度和相似度 05 第三章：序列比较（第二部分） 课时 3.7 在线双序列比对工具 3.8 BLAST搜索 06 第三章：序列比较（第三部分） 课时 3.9 多序列比对介绍 3.10 在线多序列比对工具 3.11 多序列比对的编辑和发布 3.12 寻找保守区域
1 Introduction and History of Bioinformatics 03 Bioinformatics in Mainland China 04 About This Course 01 What is Bioinformatics 02 History of Bioinformatics 1 Introduction and History of Bioinformatics 2 Sequence Alignment 05 Interview with M. S. Waterman Waterman 06 Supplement on Homology & Similarity, Similarity Matrix and Dot Matrix (English Subtitles) 03 From Global to Local 02 Global Alignment by Dynamic Programming 07 Student Presentation (English Subtitles) 04 Alignment with Affine Gap Penalty and Calculation of Time Complexity of The Needleman-Wunsch Algorithm 01 Essential Concepts 2 Sequence Alignment 3 Sequence Database Search 03 Student Presentation (English Subtitles) 02 BLAST Algorithm A Primer 01 Sequence Databases 3 Sequence Database Search 4 Markov Model 03 Predict with Hidden Markov Model 04 Student Presentation 01 From States to Markov Chain 02 Hidden Markov Model 4 Markov Model 5 Next Generation Sequencing (NGS) Mapping of Reads From Resequencing and Calling of Genetic Variants 08 Student presentation (English Subtitles) 03 Computer Lab Reads mapping and variant calling (English Subtitles) 07 A quick tour to sequencer 2 - 3730 Sanger sequencing (English Subtitles) 06 A quick tour to sequencer 1 - Ion Torrent PGM (English Subtitles) 05 Supplement on genotyping (English Subtitles) 02 Reads Mapping and Variants Calling 01 From Sequencing to NGS 04 Supplement on reads mapping and variant calling (English Subtitles) 5 Next Generation Sequencing (NGS) Mapping of Reads From Resequencing and Calling of Genetic Variants 6 Functional Prediction of Genetic Variants 02 Variant Databases 04 Classifier-Based Methods-SAPRED 01 Overview of the Problem 06 Student presentation (English Subtitles) 05 Introduction to Support Vector Machine(SVM) (English Subtitles) 03 Conservation-Based and Rule-Based Methods-SIFT & PolyPhen 6 Functional Prediction of Genetic Variants 7 Next Generation Sequencing Transcriptome Analysis, and RNA-Seq 03 Computer Lab-RNA-seq Data Analysis RNA-seq (English Subtitles) 02 RNA-Seq-Mapping & Assembling 04 Dr. Maynard Olson Talk 05 Student presentation (English Subtitles) 01 Transcriptome-An Overview 7 Next Generation Sequencing Transcriptome Analysis, and RNA-Seq 8 Prediction and Analysis of Noncoding RNA 05 A quick tour to sequencer - illumina HiSeq & MiSeq (English Subtitles) 03 Data Mining-Differential Expression and Clustering 04 Feature selection and Clustering (English Subtitles) 02 Data Mining-Identify long ncRNAs 01 From Information to Knowledge 06 Student Presentation (English Subtitles) 8 Prediction and Analysis of Noncoding RNA 9 Ontology and Identification of Molecular Pathways 05 An Application-Common Molecular Pathways Underlying Addiction 03 Annotations in Gene Ontology 01 Ontology and Gene Ontology 07 KOBAS Demo (English Subtitles) 08 Student presentation on KOBAS (English Subtitles) 04 Pathway Identification 06 Brief Introduction to Database (English Subtitles) 02 KEGG Pathway Database 9 Ontology and Identification of Molecular Pathways 10 Bioinformatics Database and Software Resources 01 Overview of Resources 04 UCSC Genome Browser 03 European Bioinformatics Institute 02 National Center for Biotechnology Information 06 CBI Resources Review (English Subtitles) 05 Individual Resources 10 Bioinformatics Database and Software Resources 11 Origination of New Genes 05 Student Presentation (English Subtitles) 03 A Human-Specific de novo Gene Associated with Addiction 01 New Gene Evolution Detected by Genomic Computation-Basic Concepts and Examples 04 Origination of de novo Genes from Noncoding RNAs 02 New Gene Evolution Detected by Genomic Computation-A Driver for Human Brain Evolution 11 Origination of New Genes 12 Evolution function analysis of DNA methyltransferase 04 Talk with Dr. Gang Pei (English Subtitles) 05 Student Presentation (English Subtitles) 03 From Dry to Wet, an Evolutionary Story Part 2 02 Project background introduction by Dr. Gang Pei 01 From Dry to Wet, an Evolutionary Story Part 1
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