在线双序列比对工具
gap open罚分小gap extend罚分大，gap分散出现，因为gap extend的代价更大
gap open罚分大gap extend罚分小，gap出现集中，因为gap open的代价更大
第三章：序列比较（第一部分）
课时
3.1 认识序列
3.2 序列相似性
3.3 替换记分矩阵
3.4 序列两两比较：打点法
3.5 序列两两比较：序列比对法
3.6 一致度和相似度
05
第三章：序列比较（第二部分）
课时
3.7 在线双序列比对工具
3.8 BLAST搜索
06
第三章：序列比较（第三部分）
课时
3.9 多序列比对介绍
3.10 在线多序列比对工具
3.11 多序列比对的编辑和发布
3.12 寻找保守区域
1 Introduction and History of Bioinformatics
03 Bioinformatics in Mainland China
04 About This Course
01 What is Bioinformatics
02 History of Bioinformatics
1 Introduction and History of Bioinformatics
2 Sequence Alignment
05 Interview with M. S. Waterman Waterman
06 Supplement on Homology & Similarity, Similarity Matrix and Dot Matrix (English Subtitles)
03 From Global to Local
02 Global Alignment by Dynamic Programming
07 Student Presentation (English Subtitles)
04 Alignment with Affine Gap Penalty and Calculation of Time Complexity of The Needleman-Wunsch Algorithm
01 Essential Concepts
2 Sequence Alignment
3 Sequence Database Search
03 Student Presentation (English Subtitles)
02 BLAST Algorithm A Primer
01 Sequence Databases
3 Sequence Database Search
4 Markov Model
03 Predict with Hidden Markov Model
04 Student Presentation
01 From States to Markov Chain
02 Hidden Markov Model
4 Markov Model
5 Next Generation Sequencing (NGS) Mapping of Reads From Resequencing and Calling of Genetic Variants
08 Student presentation (English Subtitles)
03 Computer Lab Reads mapping and variant calling (English Subtitles)
07 A quick tour to sequencer 2 - 3730 Sanger sequencing (English Subtitles)
06 A quick tour to sequencer 1 - Ion Torrent PGM (English Subtitles)
05 Supplement on genotyping (English Subtitles)
02 Reads Mapping and Variants Calling
01 From Sequencing to NGS
04 Supplement on reads mapping and variant calling (English Subtitles)
5 Next Generation Sequencing (NGS) Mapping of Reads From Resequencing and Calling of Genetic Variants
6 Functional Prediction of Genetic Variants
02 Variant Databases
04 Classifier-Based Methods-SAPRED
01 Overview of the Problem
06 Student presentation (English Subtitles)
05 Introduction to Support Vector Machine(SVM) (English Subtitles)
03 Conservation-Based and Rule-Based Methods-SIFT & PolyPhen
6 Functional Prediction of Genetic Variants
7 Next Generation Sequencing Transcriptome Analysis, and RNA-Seq
03 Computer Lab-RNA-seq Data Analysis RNA-seq (English Subtitles)
02 RNA-Seq-Mapping & Assembling
04 Dr. Maynard Olson Talk
05 Student presentation (English Subtitles)
01 Transcriptome-An Overview
7 Next Generation Sequencing Transcriptome Analysis, and RNA-Seq
8 Prediction and Analysis of Noncoding RNA
05 A quick tour to sequencer - illumina HiSeq & MiSeq (English Subtitles)
03 Data Mining-Differential Expression and Clustering
04 Feature selection and Clustering (English Subtitles)
02 Data Mining-Identify long ncRNAs
01 From Information to Knowledge
06 Student Presentation (English Subtitles)
8 Prediction and Analysis of Noncoding RNA
9 Ontology and Identification of Molecular Pathways
05 An Application-Common Molecular Pathways Underlying Addiction
03 Annotations in Gene Ontology
01 Ontology and Gene Ontology
07 KOBAS Demo (English Subtitles)
08 Student presentation on KOBAS (English Subtitles)
04 Pathway Identification
06 Brief Introduction to Database (English Subtitles)
02 KEGG Pathway Database
9 Ontology and Identification of Molecular Pathways
10 Bioinformatics Database and Software Resources
01 Overview of Resources
04 UCSC Genome Browser
03 European Bioinformatics Institute
02 National Center for Biotechnology Information
06 CBI Resources Review (English Subtitles)
05 Individual Resources
10 Bioinformatics Database and Software Resources
11 Origination of New Genes
05 Student Presentation (English Subtitles)
03 A Human-Specific de novo Gene Associated with Addiction
01 New Gene Evolution Detected by Genomic Computation-Basic Concepts and Examples
04 Origination of de novo Genes from Noncoding RNAs
02 New Gene Evolution Detected by Genomic Computation-A Driver for Human Brain Evolution
11 Origination of New Genes
12 Evolution function analysis of DNA methyltransferase
04 Talk with Dr. Gang Pei (English Subtitles)
05 Student Presentation (English Subtitles)
03 From Dry to Wet, an Evolutionary Story Part 2
02 Project background introduction by Dr. Gang Pei
01 From Dry to Wet, an Evolutionary Story Part 1
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